ArticleFish physiology and biochemistry2026
Effects of curcumin supplementation in high-fat diet on growth performance, antioxidant capacity and lipid metabolism of spotted sea bass (Lateolabrax maculatus).
Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to investigate the effects of curcumin supplementation in high-fat diets on growth performance, antioxidant capacity and lipid metabolism in spotted sea bass (Lateolabrax maculatus). Six experimental diets were formulated: a normal-fat diet (NF), a high-fat diet (HF), and four experimental diets derived from the HF supplemented with 0.02%, 0.04%, 0.08%, and 0.16% curcumin. A total of 450 healthy spotted sea bass, with an initial body weight of (2.00 ± 0.16) g, were selected and randomly allocated into 6 groups (3 replicates per group, 25 fish per replicate). The fish were raised in 200L tanks and fed the experimental diets twice daily, over a 70-day culture period. The results showed that, compared to the NF, the HF had no significant impact on weight gain rate (WGR), specific growth rate (SGR), or feed conversion ratio (FCR) in spotted sea bass (P > 0.05). The HF increased malondialdehyde (MDA) levels in the liver (P < 0.05), while reducing nuclear factor-related factor 2 (nrf2) gene expression. The levels of triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) in the serum were significantly increased (P < 0.05). Lipid deposition in the liver was significantly increased in the HF group (P < 0.05). Compared to the HF, supplementing curcumin had no significant effect on WGR, SGR, or FCR in spotted sea bass (P > 0.05). However, it increased the activity of total antioxidant capacity (0.04%) in the liver and the gene expression levels of nrf2 (0.08%) (P < 0.05), while reducing MDA levels in both serum (0.02%-0.08%) and liver (0.04%,0.16%) (P < 0.05). Compared to the HF, curcumin significantly reduced TG levels in both serum(0.04%) and liver (0.08%) of spotted sea bass (P < 0.05), markedly decreased hepatic lipid deposition (0.02%-0.16%), and significantly upregulated the expression of fatty acid β-oxidation-related genes, peroxisome proliferator-activated receptor alpha (ppar-α, 0.08%) and carnitine palmitoyltransferase I (cpt1, 0.16%), in the liver (P < 0.05). In summary, adding curcumin to high-fat diets can alleviate oxidative damage in spotted sea bass by enhancing antioxidant capacity and improve its lipid metabolism disorders. Based on antioxidant and lipid metabolism indicators, the optimal curcumin level is 0.09%.
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