ArticleAnalytical chemistry2026
Cryogenic Gas-phase IR Spectroscopy on a Commercial Ion Mobility-Mass Spectrometry Platform.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Action Spectroscopy of Mass-Selected Ions-From Principles to Applications.Journal of mass spectrometry : JMS · 2026Review
- Steroid Fingerprinting with Cryogenic Gas-Phase Infrared Spectroscopy.ACS measurement science au · 2026Article
- How to Use Quantum Chemistry for Analyzing Mass Spectrometry Data.Mass spectrometry (Tokyo, Japan) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The combination of gas-phase infrared (IR) spectroscopy with ion mobility spectrometry and mass spectrometry provides detailed, multidimensional structural information that facilitates the identification of unknown analytes. The instrumentation for performing these measurements is typically home-built and requires substantial expertise to operate. Here, we demonstrate messenger-tagging IR spectroscopy on a modified Synapt G2-S ion mobility-mass spectrometer (IM-MS). Messenger-tagging is performed in a commercially available cryogenic ion trap inserted between the exit of the transfer cell and the TOF pusher assembly, and tagged ions are excited by IR light before MS measurement. We report the adjustments to the timing cycle and voltage gradient in the Synapt G2-S necessary for efficient trapping and messenger-tagging in the cryogenic trap. The capabilities of this instrument are demonstrated by measuring IM-MS-IR data for leucine enkephalin, a benchmark standard in mass spectrometry. The ability to selectively transmit ions of specific mobility enables the separation and subsequent IR spectroscopy of the isomeric trisaccharides cellotriose and melezitose. These data demonstrate the first implementation of messenger-tagging IR spectroscopy in a widely used, commercially available IM-MS system. The user-friendly implementation of these techniques overcomes a significant barrier to the widespread incorporation of orthogonal IR spectroscopy measurements in existing IM-MS workflows and will aid in distinguishing unknown molecules in untargeted -omics measurements.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.