Observational studyTranslational vision science & technology2026
Factors Influencing Intraocular Pressure Elevation During Hemodialysis.
Observational study in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Increased Risk of Intraocular Pressure-Lowering Treatment in Patients with End-Stage Renal Disease Undergoing Hemodialysis.Ophthalmology. Glaucoma · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Purpose: The purpose of this study was to investigate intraocular pressure (IOP) and mean ocular perfusion pressure (MOPP) fluctuations during hemodialysis (HD) and identify clinical and HD-related factors associated with IOP elevation. Methods: This prospective, observational, single-center study included 103 eyes of 56 patients undergoing maintenance HD. IOP was measured at 5 time points: pre-dialysis (T0), 1 hour (T1), 2 hours (T2), 4 hours (T4), and 30 minutes post-dialysis (TP). MOPP was calculated at T0 to T4. Baseline laboratory data, including serum osmolality (PreOsm), were collected. Generalized estimating equation models evaluated the effects of time, lens status, and osmolality on IOP. Receiver operating characteristic (ROC) analysis was used to identify a PreOsm threshold for predicting IOP elevation >5 millimeters of mercury (mm Hg). Results: IOP increased during HD, peaking at 4 hours (17.5 ± 0.5 mm Hg) and returning to baseline at TP (14.6 ± 0.4 mm Hg, P < 0.001). MOPP declined over time. Phakic eyes showed significantly greater IOP at 1 and 2 hours compared with pseudophakic eyes (P = 0.022 and 0.048, respectively). Patients with PreOsm >312 milliosmolar (mOsm)/kg had greater IOP increases and were more likely to exhibit IOPrise >5 mm Hg in univariate and multivariate analyses (odds ratio [OR] = 3.94, 95% confidence interval [CI] = 1.21-12.79, P = 0.022 and OR = 3.38, 95% CI = 1.01-11.3, P = 0.048, respectively). Phakic lens status was associated with IOP elevation in univariate analysis (OR = 2.38, 95% CI = 1.01-5.56, P = 0.049), but in multivariate analysis, there was only a trend (P = 0.072). Conclusions: Transient intra-dialytic IOP elevation may be influenced by osmolality more so than lens status. Translational Relevance: These findings support the concept of ocular disequilibrium during HD and highlight the need for targeted ophthalmic monitoring in high-risk patients.
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Registered trials
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