Evidence map›Paper›PMID 42101371›Full record

ArticlePediatric pulmonology2026

Function and Structure Relationships With Inflammation Differ in Two Chronic Suppurative Lung Diseases.

Teresa Fuchs, Jacqueline Donovan, Andrew Ives, Samantha Irving, Gwyneth Davies, Claire Hogg, Eric Alton, Gemma Wilson, Andrew Bush, Jane C Davies

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Teresa FuchsNational Heart & Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-1002-1185
Jacqueline DonovanNational Heart & Lung Institute, Imperial College London, London, UK.
Andrew IvesNational Heart & Lung Institute, Imperial College London, London, UK.
Samantha IrvingNational Heart & Lung Institute, Imperial College London, London, UK.
Gwyneth DaviesPopulation Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK.
Claire HoggNational Heart & Lung Institute, Imperial College London, London, UK.
Eric AltonNational Heart & Lung Institute, Imperial College London, London, UK.
Gemma WilsonNational Heart & Lung Institute, Imperial College London, London, UK.
Andrew BushNational Heart & Lung Institute, Imperial College London, London, UK.
Jane C DaviesNational Heart & Lung Institute, Imperial College London, London, UK.

Funding

Brompton Clinical Research FacilityCystic Fibrosis TrustNational Institute for Health & Care Research
6 · The paper itself

Abstract

rationaleCystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are characterized by neutrophilic airway inflammation but differ in clinical features.

objectivesWe investigated relationships of pulmonary and systemic inflammatory markers with functional and structural lung disease.

methodsSystemic (CRP, IgG, IL-6, and IL-8) and sputum (calprotectin, IL-6, and IL-8) markers were measured at baseline. Relationships were explored with spirometry, lung clearance index and lung computed tomography (CT) scores at baseline and with spirometry 10 years later.

results42 patients (21 CF, 21 PCD) of similar age (median CF 27 y [12-59], PCD 27 y [11-62]) and lung function (median ppFEV

conclusionThis study emphasizes the differences of functional and structural aspects in both diseases. Markers that predict long-term outcome in PCD and in CF were identified. The most striking and unanticipated finding was that sputum IL-6 correlated with better CT scores and lung function in CF. This paradox merits further research but challenges whether sputum IL-6 in CF is always a bad prognostic indicator.

Indexed as

Cystic FibrosisInflammationKartagener SyndromeLungAdolescentAdultBiomarkersChildChronic DiseaseC-Reactive ProteinFemaleHumansInterleukin-6Interleukin-8MaleMiddle AgedBiomarkersC-Reactive ProteinInterleukin-6Interleukin-8cystic fibrosisinflammationlong‐termprimary ciliary dyskinesiasputum

Identifiers

PMID42101371
PMCPMC13155176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.