ArticleAging cell2026
Targeting Hyperoxia-Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants.
Maunick Lefin Koloko Ngassie, Li Y Drake, Yi Zhu, Yamillie Ortiz, Daniel A Pfeffer-Kleemann, Michael A Thompson, Samantha K Hamrick, Christina M Pabelick, Y S Prakash
Abstract read
In one paragraphArticle in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Li Y DrakeDepartment of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, USA.
Yi ZhuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Yamillie OrtizDepartment of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, USA.
Daniel A Pfeffer-KleemannDepartment of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, USA.
Michael A ThompsonDepartment of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, USA.
Samantha K HamrickDepartment of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, USA.
Christina M PabelickDepartment of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, USA.
Y S PrakashDepartment of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, USA.
Funding
NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5MCellular Senescence in Neonatal AirwaysR01HL158532 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 2022 to 2025
$2.5MCellular Senescence in Trisomy 21 lung diseaseR01HL171915 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Denise Al Alam, Christina Maria Pabelick · 2024 to 2026
$1.8MInvestigating the Role of Adipose Senescent Cells in Cognitive Function and Alzheimer's Disease ProgressionR01AG087387 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Yi Zhu · 2024 to 2026
$1.5MNHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL158532NHLBI NIH HHS R01 HL171915NIA NIH HHS R01 AG087387
6 · The paper itselfAbstract
Supplemental oxygen (hyperoxia), often provided to premature infants, can disrupt lung growth and contribute to development of neonatal and pediatric lung diseases, necessitating understanding of underlying mechanisms. We previously showed that even moderate hyperoxia (< 60% O
Indexed as
AntioxidantsCellular SenescenceHyperoxiaSenotherapeuticsCell SurvivalDasatinibHumansMyocytes, Smooth MuscleOrganophosphorus CompoundsPolysaccharidesQuercetinUbiquinoneAntioxidantsDasatinibfucoidanmitoquinoneOrganophosphorus CompoundsPolysaccharidesQuercetinSenotherapeuticsUbiquinoneasthmabronchopulmonary dysplasiaDasatinibFucoidanlung developmentMitoQoxygenQuercetin
Identifiers
PMID42101153
PMCPMC13154765
What OpenQuestion holds
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