ArticlePediatric pulmonology2026
Spirometry Assessments in Children With Sickle Cell Disease in Ghana.
Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Factors Associated with Uninterpretable Spirometry During Asthma Screening in Children with Sickle Cell Disease: An Expanded Multicenter Study in French Guiana.Children (Basel, Switzerland) · 2026Article
- Spirometry Assessments in Children With Sickle Cell Disease in Ghana.Pediatric pulmonology · 2026Article
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10 authors.
Funding
Abstract
backgroundPulmonary disease in children with SCD is common and heterogeneous and includes pulmonary function impairment. This study aimed to investigate spirometry patterns in Ghanaian children with SCD and factors that contribute to low lung function.
methodsA case-control study involving children aged 6-16 years with and without SCD was carried out at the Komfo Anokye Teaching Hospital. Demographic, socio-economic, and clinical information were collected. Spirometry was performed for both cases and controls at enrolment and interpreted based on the GLI-Black reference equation. Logistic and linear regression analyses were performed.
resultsA total of 115 cases and 115 controls were recruited for the study. Children with SCD had significantly lower anthropometric measurements, lower lung volumes compared to the controls: median (IQR) BMI z-scores; cases vs controls, -0.5 (-1.3 to 0.3); versus -0.2 (-0.9 to 0.8) p = 0.01, mean z- scores for forced expiratory volume in 1 s (FEV
conclusionThis study has demonstrated a predominance of low anthropometric measurements and restrictive abnormality on spirometry in children with SCD in Ghana. Females and those with higher BMI z-scores had significantly lower odds of having a restrictive lung function pattern compared to normal lung function.
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