ArticleEuropean journal of pain (London, England)2026
Behavioural Characterisation and Pharmacological Validation of an Incisional Wound-Related Pain Model.
Article in European journal of pain (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWound-related pain represents a significant unmet clinical need. To advance its understanding and treatment, there is a need for a validated preclinical model for the study of wound-related pain in both sexes.
methodsA 1.2 cm incision was created on the hairy skin of the dorsum of male and female Sprague-Dawley rats posterior to L4. In the first study, mechanical withdrawal thresholds at the dorsum and hind paws were assessed for 34 days post-incision in both male and female rats to investigate the temporal profile of mechanical hypersensitivity following a dorsum incision. The second study investigated the effects of morphine (3 mg/kg s.c.) on mechanical hypersensitivity in the dorsum and hind paws on post-incision Day 8 in male Sprague-Dawley rats.
resultsRobust mechanical hypersensitivity was evident in the dorsum up to 14 days post-incision in males and 7 days post-incision in females, indicating sex differences in the temporal profile of mechanical hypersensitivity following incision. Secondary mechanical hypersensitivity was present in the hind paws of both sexes following a dorsum incision. Morphine (3 mg/kg s.c.) significantly attenuated dorsum and hind paw mechanical hypersensitivity on post-incision Day 8.
conclusionsThese results suggest that the dorsum incision model is suitable for modelling incisional wound-related pain and exhibits sex differences in pain-related behaviour post-incision. SIGNIFICANCE: This paper extends the characterisation of an animal model of incisional wound-related pain, in both sexes. It represents an advancement in the ability to model this condition pre-clinically and will facilitate investigation of underlying mechanisms and novel therapeutics.
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