ArticlePain practice : the official journal of World Institute of Pain2026
The Patterns and Trajectory of Continued Opioid Use in Opioid-Naïve Patients After Curative-Intent Elective Cancer Surgery-A Prospective Cohort Study.
Article in Pain practice : the official journal of World Institute of Pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Racial and ethnic differences in opioid fills following cancer-directed surgery among older and younger Medicare beneficiaries.Journal of the National Cancer Institute · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-discharge opioid use patterns in opioid-naïve patients following cancer surgery remain poorly characterized, particularly during the early transition period after discharge.
aimTo determine the prevalence of continued opioid use 7 days after discharge and to identify predictors and cessation trajectories over 30 days post-discharge.
methodsA prospective single-center cohort study enrolled opioid-naïve patients undergoing curative-intent elective cancer surgery across three surgical specialties (breast, gynecological oncology, and head and neck) between June 2021 and January 2023. The primary outcome was patient-reported opioid use at Day 7 post-discharge. Multivariable logistic regression identified independent predictors; Kaplan-Meier analysis estimated time-to-cessation by pre-discharge opioid exposure group.
resultsAmong 107 opioid-naïve patients, 42% continued opioid use beyond 7 days. Patients who continued opioids had higher pain interference, more opioid-related adverse events, and higher opioid consumption during 24 h prior to discharge (p < 0.05). In multivariable analysis, having opioids in 24 h prior to discharge (adjusted odds ratio [aOR] 4.46; 95% CI 1.56-12.7), first-time cancer surgery (aOR 6.06; 95% CI 1.45-25.6), and higher stage of cancer (aOR 1.50; 95% CI 1.00-2.23) were independently associated with continued opioid use. Kaplan-Meier graph analysis demonstrated significantly different cessation trajectories between pre-discharge opioid exposure groups (log rank p < 0.001).
conclusionContinued opioid use in the first week following cancer surgery is common. Pre-discharge opioid exposure and disease burden independently predict delayed cessation. Opioid use in the final 24 h before discharge represents a practical, clinically accessible signal for risk stratification and individualized opioid stewardship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.