Distinct macrophage and microglia function in ischemic stroke.

Dengxing Li, Bao Liao, Huimin Wei, Fengmei Li, Jinyong Teng, Lili Wei, Yueyuan Huang, Qin Yang, Shaofa Li

Abstract read

In one paragraph

Article in Journal of biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dengxing LiBaise People's Hospital, Baise, Guangxi, China.

Bao LiaoBaise People's Hospital, Baise, Guangxi, China.

Huimin Wei

Fengmei LiBaise People's Hospital, Baise, Guangxi, China.

Jinyong TengBaise People's Hospital, Baise, Guangxi, China.

Lili WeiBaise People's Hospital, Baise, Guangxi, China.

Yueyuan HuangBaise People's Hospital, Baise, Guangxi, China.

Qin YangBaise People's Hospital, Baise, Guangxi, China.

Shaofa LiBaise People's Hospital, Baise, Guangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to explore the characteristics and differentiation pathways of microglia and macrophages using single-cell transcriptome data from mouse stroke models. The clusters of microglia and macrophages in the middle cerebral artery occlusion model mouse brain were identified using the Seurat package. The signaling pathways were evaluated through Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes analyses, while transcription factor activity was analyzed using DecoupleR. Monocle2 was employed to infer the differentiation trajectory of microglia and macrophages, exploring changes in gene expression patterns during their activation process using gene dynamics analysis. Additionally, the self-differential and overlapping subclusters of macrophages and microglia following cerebral ischemia were assessed, and CellChat was used to analyze differences in cell communication. An

Indexed as

Brain IschemiaForkhead Box Protein O1Infarction, Middle Cerebral ArteryIschemic StrokeMacrophagesMicrogliaAnimalsCell DifferentiationChemokine CCL2Disease Models, AnimalGene Expression RegulationGlucoseInterferon-gammaMaleMicePhagocytosisCcl2 protein, mouseChemokine CCL2Forkhead Box Protein O1Foxo1 protein, mouseGlucoseInterferon-gammaTnf protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID42100980

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.