Nickel-Catalyzed Carbonylative Synthesis of β-Ketonitriles from α-Bromonitriles and Arylboronic Acids.

Jiacong Ma, Yuting Jiang, Zilin Huang, Xinxin Qi, Xiao-Feng Wu

Abstract read

In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Nickel-Catalyzed Carbonylative Synthesis of β-Ketonitriles from α-Bromonitriles and Arylboronic Acids.Organic letters · 2026
Article

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jiacong MaSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Yuting JiangSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Zilin HuangSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Xinxin QiSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Xiao-Feng WuDalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China.ORCID 0000-0001-6622-3328

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new carbonylation reaction of α-bromonitriles with arylboronic acids has been explored for the synthesis of β-ketonitriles. Notably, the reaction is catalyzed by an inexpensive nickel catalyst and operates under mild reaction conditions without the direct use of gaseous CO. It demonstrates a general and complementary carbonylation route for the synthesis of valuable β-ketonitrile products, and a variety of products were obtained in moderate to high yields with good functional group tolerance. Moreover, the synthetic utility of this method is evidenced by a scale-up experiment and subsequent functionalization of the resulting β-ketonitriles.

Identifiers

PMID42100859

DOI10.1021/acs.orglett.6c01685

PMCPMC13200237

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