Evidence map›Paper›PMID 42100807›Full record

ReviewStroke2026

Transcranial Direct Current Stimulation for Stroke Motor Recovery: What the TRANSPORT2 Trial Taught Us.

Christy Cassarly, Salman Ikramuddin, Gottfried Schlaug, Ahlam Salameh, Steven L Wolf, Joseph P Broderick, Jody A Feld, Stacy Fritz, Veronica T Rowe, Wuwei Feng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christy CassarlyDepartment of Public Health Sciences, Medical University of South Carolina, Charleston (C.C.).ORCID 0000-0002-0304-9833
Salman IkramuddinDepartment of Neurology (S.I., J.A.F., W.F.), School of Medicine, Duke University, Durham, NC.ORCID 0009-0006-6493-6635
Gottfried SchlaugDepartment of Public Health Sciences, Medical University of South Carolina, Charleston (C.C.).
Ahlam SalamehDepartment of Neurology, Case Western Reserve University, Cleveland, OH (A.S.).ORCID 0000-0003-1687-6093
Steven L WolfDepartment of Rehabilitation Medicine, Emory University, Atlanta, GA (S.L.W.).ORCID 0000-0002-9446-8995
Joseph P BroderickDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati Gardner Neuroscience Institute, University of Cincinnati, OH (J.P.B.).ORCID 0000-0002-7323-7709
Jody A FeldDepartment of Orthopaedic Surgery (J.A.F.), School of Medicine, Duke University, Durham, NC.ORCID 0000-0002-1349-8675
Stacy FritzPhysical Therapy Program, Arnold School of Public Health, University of South Carolina, Columbia (S.F.).ORCID 0000-0002-1663-1152
Veronica T RoweDepartment of Occupational Therapy, Georgia State University, Atlanta (V.T.R.).ORCID 0000-0001-5943-5074
Wuwei FengDepartment of Neurology (S.I., J.A.F., W.F.), School of Medicine, Duke University, Durham, NC.ORCID 0000-0001-6230-4905

Funding

Workshop to Identify Collaborative Project(s) for the NIH StrokeNet and the Japan NEtwork for Clinical Stroke Trials (NECST)U01NS087748 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Catherine R. Dillon, Jordan J. Elm · 2014 to 2026
$14.1M
TRANScranial direct current stimulation for POst-stroke motor Recover - a phase II sTudy (TRANSPORT 2)U01NS102353 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FENG, WUWEI, SCHLAUG, GOTTFRIED · 2018 to 2023
$8.5M
Dissecting Behavioral and Neural Mechanisms of Hand Dexterity after Stroke for Effective RehabilitationR01NS130210 · NINDS · UNIVERSITY OF GEORGIA · PI XU, JING · 2023 to 2025
$1.7M
Duke-University of North Carolina (UNC) Eastern North Carolina and Southern Virginia RegIonal Stroke trIal cONsortium (ENVISION)U24NS135250 · NINDS · DUKE UNIVERSITY · PI Wuwei Feng, David Yi-Gin Hwang · 2024 to 2026
$1.2M
NINDS NIH HHS R01 NS130210NINDS NIH HHS U01 NS087748NINDS NIH HHS U01 NS102353NINDS NIH HHS U24 NS135250
6 · The paper itself

Abstract

Over the past 2 decades, transcranial direct current stimulation has attracted substantial interest as an adjunctive strategy to enhance poststroke motor recovery. In addition to its potential neuromodulatory effects on motor cortical networks, transcranial direct current stimulation devices are low-cost, easy to use, and compatible with concurrent rehabilitation. Yet, despite its promise, several barriers hinder translation into routine clinical practice, including neutral results from several recently completed multicenter trials, such as TRANSPORT2 (Transcranial Direct Current Stimulation for Post-Stroke Motor Recovery). Moving forward, progress will depend on addressing issues in 3 broad domains: device-related (stimulation parameters and montage), disease-related (patient characteristics and timing), and trial design (outcomes, analytical approaches, adjunctive therapy, and trial infrastructure). In this topical review, we critically examine these challenges and outline strategies to refine transcranial direct current stimulation application, with the goal of more effectively leveraging its neuromodulation properties to promote neuroplasticity and enhance motor recovery after stroke.

Indexed as

Motor CortexStrokeStroke RehabilitationTranscranial Direct Current StimulationClinical Trials, Phase II as TopicHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicRecovery of FunctionTreatment Outcomearmmotor disordersnerve regenerationneurological rehabilitationstroketranscranial direct current stimulation

Identifiers

PMID42100807
PMCPMC13160230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.