Evidence map›Paper›PMID 42100790›Full record

ArticleHemaSphere2026

Fitusiran treatment modulates the ratio between alpha- and beta-antithrombin isoforms.

Geneviève McCluskey, Hortense Maynadié, Delphine Borgel, Laurent Frenzel, Annie Harroche, Elsa Bianchini, Stephanie Roullet, Olivier D Christophe, Cecile V Denis, Caterina Casari and 1 more

Abstract read
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Geneviève McCluskeyINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.
Hortense MaynadiéINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.
Delphine BorgelINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.
Laurent FrenzelService d'Hématologie Adulte Hôpital Necker Enfants Malades AP-HP Paris France.
Annie HarrocheCentre de Traitement de l'Hémophilie, AP-HP, Hôpital Necker Enfants Malades Paris France.
Elsa BianchiniINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.
Stephanie RoulletINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.
Olivier D ChristopheINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.
Cecile V DenisINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.
Caterina CasariINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.
Peter J LentingINSERM, Hémostase Inflammation Thrombose HITh U1176 Université Paris-Saclay Le Kremlin-Bicêtre France.ORCID https://orcid.org/0000-0002-7937-3429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antithrombin (AT) circulates as two distinct isoforms, alpha- and beta-AT, which differ in their glycosylation profiles; alpha-AT is fully glycosylated at positions Asn

Identifiers

PMID42100790
PMCPMC13146349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.