Evidence map›Paper›PMID 42100770›Full record

ArticleFrontiers in psychiatry2026

How family functioning shapes prenatal bonding: a mediation analysis of depressive symptoms and maternal-fetal attachment.

Silvia Mammarella, Laura Giusti, Laura Camoni, Fiorino Mirabella, Manuela Ludovisi, Rita Roncone

Abstract read
In one paragraph

Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Silvia MammarellaDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Laura GiustiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Laura CamoniCenter for Behavioural Sciences and Mental Health, National Institute of Health, Rome, Italy.
Fiorino MirabellaCenter for Behavioural Sciences and Mental Health, National Institute of Health, Rome, Italy.
Manuela LudovisiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Rita RonconeDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Pregnancy is a period in a woman's life characterized by profound hormonal, psychological, and social changes, which may lead to increased emotional vulnerability, during which depressive symptoms may negatively affect maternal well-being and maternal-fetal attachment. Although family functioning has traditionally been examined mainly in relation to psychopathology, its protective role during pregnancy remains insufficiently explored. This study examined whether depressive symptoms mediate the association between family functioning and antenatal maternal attachment. Methods: The sample consisted of 261 pregnant women enrolled in a multicenter Italian perinatal mental health project. The present add-on study focused specifically on family functioning, social support, and maternal antenatal attachment. Participants completed self-report measures assessing depressive symptoms (Edinburgh Postnatal Depression Scale), maternal-fetal attachment (Maternal Antenatal Attachment Scale), family functioning (Family Functioning Questionnaire), perceived partner support, and social network quality. Structural equation modeling was used to test a mediation model in which depressive symptoms mediated the relationship between family functioning and two attachment dimensions: quality of attachment and intensity of preoccupation. Models were estimated using full-information maximum likelihood with bootstrapped confidence intervals. Results: Higher family functioning was significantly associated with lower depressive symptom severity. Depressive symptoms were negatively associated with attachment quality but not with intensity of preoccupation. A small but significant indirect effect of family functioning on attachment quality, mediated by depressive symptoms, emerged, indicating partial mediation. No mediation effect was observed for intensity of preoccupation, which showed a direct positive association with family functioning. These results remained substantially unchanged after controlling for perceived partner support and social network quality. Conclusion: Depressive symptoms partially mediate the relationship between family functioning and the emotional quality of maternal-fetal attachment, whereas the intensity of preoccupation appears to be more directly linked to the broader family environment. These findings underscore the importance of assessing family functioning during pregnancy and suggest that interventions targeting both family dynamics and maternal depressive symptoms may foster healthier prenatal attachment.

Indexed as

depressive symptomsfamily functioningmaternal–fetal attachmentmediation modelperinatal mental healthpregnancy

Identifiers

PMID42100770
PMCPMC13143980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.