Evidence map›Paper›PMID 42100747›Full record

ArticleiScience2026

RIPOR2 promotes multinucleation of melanoma cells downstream of the RAS/ERK oncogenic pathway.

Axelle Wilmerding, Aurélie Richard, Nicolas Macagno, Estelle Hirsinger, Tarek Gharsalli, Léa Bellenger, Naïra Naouar, Caroline Gaudy, Stéphanie Mallet, Nathalie Degardin and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Axelle WilmerdingAix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
Aurélie RichardUniversité Paris Cité (EDC), CNRS, UMR7216 Epigenetics and Cell Fate, 75013 Paris, France.
Nicolas MacagnoDepartment of Pathology, APHM, Timone University Hospital, Marseille, France.
Estelle HirsingerDéveloppement, Adaptation et Vieillissement (Dev2A), Sorbonne Université-CNRS UMR8263, Inserm U1345, Institut Biologie Paris Seine, Paris, France.
Tarek GharsalliDéveloppement, Adaptation et Vieillissement (Dev2A), Sorbonne Université-CNRS UMR8263, Inserm U1345, Institut Biologie Paris Seine, Paris, France.
Léa BellengerInstitut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-FR3631, InforBio, Inserm U1156, Paris, France.
Naïra NaouarInstitut Biologie Paris Seine, Sorbonne Université, CNRS, IBPS-FR3631, InforBio, Inserm U1156, Paris, France.
Caroline GaudyDepartment of Oncodermatology, APHM, Timone University Hospital, Marseille, France.
Stéphanie MalletDepartment of Oncodermatology, APHM, Timone University Hospital, Marseille, France.
Nathalie DegardinDepartment of Pediatric Plastic Surgery, APHM, Timone University Hospital, Marseille, France.
Lauranne BouteilleAix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
Nathalie CarusoAix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
Delphine DuprezDéveloppement, Adaptation et Vieillissement (Dev2A), Sorbonne Université-CNRS UMR8263, Inserm U1345, Institut Biologie Paris Seine, Paris, France.
Yacine GrabaAix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.
Souhila MedjkaneUniversité Paris Cité (EDC), CNRS, UMR7216 Epigenetics and Cell Fate, 75013 Paris, France.
Heather C EtcheversAix-Marseille University, INSERM, MMG, U1251, Institut MarMaRa, Marseille, France.
Marie-Claire DelfiniAix-Marseille University, CNRS, IBDM, UMR 7288, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multinucleation in cancer has been shown to promote aneuploidy, which correlates with tumor aggressiveness. This is particularly true for melanoma, a cancer caused by excessive proliferation of melanocytes, whose RAS/ERK pathway is overactivated. Using single-nucleus RNA sequencing after overactivation of the RAS/ERK pathway in the chicken embryo as an

Indexed as

cancercell biologymolecular biology

Identifiers

PMID42100747
PMCPMC13145898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.