Evidence map›Paper›PMID 42100713›Full record

ArticleClinical kidney journal2026

Immunogenicity and reactogenicity of the adjuvanted respiratory syncytial virus vaccine in patients with chronic kidney disease.

Richard Radun, Saskia Bronder, Amina Abu-Omar, Danilo Fliser, Martina Sester, David Schmit

Abstract read
In one paragraph

Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Richard RadunDepartment of Internal Medicine IV, Saarland University Medical Center, Campus Homburg, Homburg, Germany.
Saskia BronderDepartment of Transplant and Infection Immunology, PharmaScienceHub (PSH), Saarland University, Homburg, Germany.
Amina Abu-OmarDepartment of Internal Medicine IV, Saarland University Medical Center, Campus Homburg, Homburg, Germany.
Danilo FliserDepartment of Internal Medicine IV, Saarland University Medical Center, Campus Homburg, Homburg, Germany.
Martina SesterDepartment of Transplant and Infection Immunology, PharmaScienceHub (PSH), Saarland University, Homburg, Germany.ORCID https://orcid.org/0000-0001-5482-0002
David SchmitDepartment of Internal Medicine IV, Saarland University Medical Center, Campus Homburg, Homburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic kidney disease (CKD) contributes to global mortality and morbidity, also due to infectious complications resulting from immune system dysregulation. Recently, respiratory syncytial virus (RSV) vaccines based on the prefusion F (preF) glycoprotein have been licensed for prevention of severe disease in elderly and in patients with comorbidities, but data on immunogenicity in patients with CKD are scarce. Methods: We characterized humoral and cellular immunogenicity of 75 patients with CKD stages G3a to G5d both before and 14 days (IQR 2) after vaccination with an adjuvanted protein-based RSVpreF3-vaccine using ELISA and flow cytometry. Data on adverse events were collected through a self-reported questionnaire. Results: Vaccination led to a significant induction of RSV-specific CD4 T cells ( Conclusions: RSV-vaccination led to a robust CD4 T-cell and humoral response in patients with CKD with less pronounced effects in those with high-grade proteinuria. Long-term data on immunogenicity and correlation with clinical outcomes are warranted to define optimal vaccination strategies.

Indexed as

chronic kidney diseaseimmunoglobulinsrespiratory syncytial virusRSVpreF3-vaccinationT cells

Identifiers

PMID42100713
PMCPMC13146607

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.