Evidence map›Paper›PMID 42100710›Full record

ArticleBone reports2026

Pulsed electromagnetic field drives osteogenic and suppresses adipogenic differentiation of bone marrow mesenchymal stem cells

Jian Wei, Zhiyang He, Jiayue Xie, Fang Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jian WeiDepartment of Joint Orthopedics, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, 545006, China.
Zhiyang HeDepartment of Joint Orthopedics, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, 545006, China.
Jiayue XieDepartment of Joint Orthopedics, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, 545006, China.
Fang XuDepartment of Joint Orthopedics, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, 545006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pathological shift in bone marrow mesenchymal stem cell (BMSC) differentiation towards adipogenesis at the expense of osteogenesis is a key cellular driver of osteoporosis induced by glucocorticoids or estrogen deficiency. Pulsed electromagnetic field (PEMF) therapy shows clinical promise for bone disorders, yet its capacity to directly correct this lineage imbalance and the specific molecular mechanisms involved remain insufficiently defined. Here, we demonstrate that PEMF (75 Hz, 1.5 mT) directly counteracts dexamethasone (Dex)-induced effects in rat BMSCs, promoting osteogenic differentiation and concurrently suppressing adipogenesis

Indexed as

Bone marrow adipose tissueBone marrow mesenchymal stem cellsDifferentiationOsteoporosisPulsed electromagnetic fieldWnt/β-catenin signaling

Identifiers

PMID42100710
PMCPMC13147369

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.