Evidence map›Paper›PMID 42100655›Full record

ReviewFrontiers in cellular and infection microbiology2026

The therapeutic potential of epimedium and its bioactive flavonoids in hepatitis and cirrhosis: an integrative review.

Jianyi Zhang, Weichi Jiang, Huigang Feng, Rui Yan, Yi Huang, Qiwei Liang, Ningyi Zhang, Haoming Huang, Yujin Wu, Chunhua Fan and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jianyi ZhangGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Weichi JiangOncology Department, Guangdong Provincial Second Hospital of Traditional Chinese Medicine, Guangzhou, China.
Huigang FengIntervention Department, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
Rui YanInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yi HuangIntervention Department, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
Qiwei LiangIntervention Department, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
Ningyi ZhangGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Haoming HuangGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Yujin WuGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Chunhua FanGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Yilin YangGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Yuan LiaoGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Xiliang HuangGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Jiawei FanGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Ping ZengGastroenterology Department, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Jinming LiGuangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics and Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal University, Guangzhou, China.
Hanwei ChenIntervention Department, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis and cirrhosis constitute a substantial global health burden, with therapeutic options remaining largely confined to antiviral agents and liver transplantation. Traditional Chinese medicine has long employed Epimedium species (Berberidaceae) for hepatoprotective indications, with contemporary investigations identifying prenylated flavonoids-principally icariin and its active metabolite icaritin-as the principal bioactive constituents. This integrative review systematically examined 33 high-impact studies published up to March 2026, selected based on a comprehensive search of PubMed, Web of Science, Scopus, Embase, Cochrane Library, CNKI, Wanfang, and Google Scholar. Included investigations were critically evaluated for mechanistic sophistication, translational validity, methodological rigor, and pharmacokinetic relevance. Preclinical evidence, derived predominantly from toxin-induced (e.g., CCl

Indexed as

EpimediumFlavonoidsHepatitisLiver CirrhosisAnimalsAntiviral AgentsHumansAntiviral AgentsFlavonoidsicariinicaritinanti-fibrotic therapycirrhosisepimediumhepatic stellate cellhepatitisicariinicaritin

Identifiers

PMID42100655
PMCPMC13143968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.