Trial reportFrontiers in human neuroscience2026
fNIRS-Guided neuronavigated rTMS augments naming recovery in subacute post-stroke aphasia: a double-blind randomized controlled trial.
Trial report in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Neuromodulation for post-stroke aphasia rehabilitation: established cortical stimulation and emerging network-based targets.Frontiers in human neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Selecting an optimal stimulation target is a persistent barrier to maximizing the efficacy of repetitive transcranial magnetic stimulation (rTMS) for subacute post-stroke aphasia. This trial evaluated an individualized, fNIRS-based targeting strategy derived from task-evoked activation during picture naming. Methods: We conducted a double-blind, randomized, sham-controlled clinical trial. Patients with first-ever left-hemispheric stroke and subacute aphasia (1-6 months post-onset; 35-80 years) were recruited at Huashan Hospital (2021-2023) and randomized 1:1 to receive fNIRS-guided active rTMS or fNIRS-guided sham stimulation, in addition to 3 weeks of intensive speech-language therapy. Individual targets were defined as the fNIRS channel showing the strongest picture-naming task activation and were delivered under neuronavigation. Active stimulation used 10 Hz, 80% resting motor threshold, 2,000 pulses per session, for 15 sessions (3 weeks); sham used an identical schedule with a sham configuration. Primary/secondary outcomes included the Chinese Boston Naming Test (BNT), WAB-R indices, picture-naming behavioral performance, and task/resting-state fNIRS measures. Results: Twenty-eight participants were enrolled and 27 completed the protocol (active rTMS: Conclusion: fNIRS-guided rTMS protocol based on individualized, task-evoked activation mapping is a safe and effective approach for improving picture-naming performance in patients with subacute post-stroke aphasia. The intervention yields promising short-term therapeutic benefits and is associated with enhanced activation in the left dorsolateral prefrontal cortex and Broca's area, as well as strengthened functional connectivity between these language-related regions. Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=61768, Unique identifier: ChiCTR2000038515.
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