Evidence map›Paper›PMID 42100417›Full record

ArticleFrontiers in oncology2026

VA/VHAG alternating consolidation regimen combined with umbilical cord blood and mesenchymal stem cell infusion for the treatment of high-risk MDS patients who are unfit for transplantation: a case report and literature review.

Qixin Sun, Zhenzhen Wen, Yanying Ling, Jiongxiang Kuang, Guiping Chen, Zhigang Zhu, Hong Wang, Kangbao Li

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qixin SunDepartment of Geriatric Hematology and Oncology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Zhenzhen WenBlood Purification Center, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Yanying LingClinical Laboratory Department, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Jiongxiang KuangDepartment of Trauma and Orthopedics, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Guiping ChenDepartment of Geriatric Hematology and Oncology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Zhigang ZhuDepartment of Geriatric Hematology and Oncology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Hong WangDepartment of Geriatric Gastroenterology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Kangbao LiDepartment of Geriatric Hematology and Oncology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The only treatment option for high-risk MDS patients unfit for transplantation is continuous treatment with a hypomethylating agent (HMA). In this context, some new combination HMA regimens and other drugs with different mechanisms of action have been developed recently; however, no breakthroughs have been made. In our clinical practice, we have gradually explored various new methods-induction therapy with a modified VIALE-A (VA) regimen and an alternating regimen of modified VA and VHAG for the consolidation period. Some patients who were persistently positive for MRD were treated with HLA-mismatched umbilical cord blood, and patients with poor hematopoietic recovery additionally received mesenchymal stem cells infusion. Together, these treatments showed good efficacy. Here, the total treatment process for a typical patient is described, and a review of the literature is provided.

Indexed as

mesenchymal stem cellmyelodysplastic syndrometreatmentumbilical cord bloodvenetoclax

Identifiers

PMID42100417
PMCPMC13143606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.