ArticleFrontiers in oncology2026
Case Report: A case of non-secretory multiple myeloma presenting with eosinophilia: diagnostic challenges and a focused literature review.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
We report a rare case of non-secretory multiple myeloma (NSMM) presenting with marked eosinophilia and considerable diagnostic difficulty. A 56-year-old man was admitted with recurrent low back pain of more than 10 years' duration that had rapidly worsened over the preceding 10 days, accompanied by diffuse pain and weight loss. Laboratory evaluation showed persistent eosinophilia, thrombocytopenia, elevated lactate dehydrogenase, and increased inflammatory markers. Imaging revealed multifocal osteolytic lesions involving the skull, vertebrae, ribs, and pelvis. However, serum and urine immunofixation electrophoresis were negative, qualitative urine Bence-Jones protein testing was negative, and repeated serum free light chain testing showed a normal κ/λ ratio, making the diagnosis particularly challenging. Bone marrow aspirate showed marked eosinophilia, and flow cytometry identified clonal plasma cells accounting for 6.1% of nucleated cells. Bone marrow biopsy with immunohistochemistry confirmed a plasma-cell neoplasm, while myeloma fluorescence
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