ArticleIranian journal of child neurology2026
Hyperventilation-Induced High-Amplitude Rhythmic Slowing and Its Impact on Migraine Frequency in Children: A Retrospective Observational Cohort Study.
Article in Iranian journal of child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: The most common primary headache disorder in children is migraine. Some children with hyperventilation (HV) may exhibit hyperventilation-induced high-amplitude rhythmic slowing (HIHARS) in their electroencephalogram (EEG). The study aims to evaluate the correlation between HIHARS and a child's future migraine onset risk. Materials & Methods: The present study evaluated HIHARS during the HV maneuver in children aged 7 to 12 admitted to the Electroencephalography Monitoring Unit for diverse referral reasons. After six years, the researchers assessed Long-term video-EEG monitoring data for migraine disease according to the International Classification of Headache Disorders, Third Edition (ICHD-3). The clinical and neurophysiological data were analyzed using appropriate statistical methods. Results: The study revealed that among children with HIHARS, migraine was higher (P=0.049) after six years. Additionally, 15 children (68.18%) with HIHARS had a family history of migraine, compared to 12 children (40%) without HIHARS, which was significant (P=0.044). Interestingly, no significant difference was observed between patients with seizures and those without (P=0.1), suggesting that seizures do not act as a confounding factor in this study. Conclusion: This is the first study on the correlation of HIHARS with migraine in children. Patients aged 7 to 12 years old with HIHARS had more susceptibility to migraine headaches. It is suggested that children with HIHARS and a history of migraine in first-degree family members will be more susceptible to developing migraine in life.
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