Evidence map›Paper›PMID 42100328›Full record

ArticleFrontiers in pharmacology2026

Tetracycline reprograms inflammatory and regenerative signaling pathways in human keratinocytes exposed to

Bruna Fernandes Pinto, Priscila Hess Lopes, Carlos Eduardo Madureira Trufen, Ana Tung Ching Ching, Inácio de Loiola Meirelles Junqueira de Azevedo, Milton Yutaka Nishiyama-Jr, Denise V Tambourgi

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bruna Fernandes Pinto *Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Priscila Hess Lopes *Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Carlos Eduardo Madureira TrufenPREVOR, Liège, Belgium.
Ana Tung Ching ChingImmunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Inácio de Loiola Meirelles Junqueira de AzevedoLaboratory of Applied Toxinology, Butantan Institute, São Paulo, Brazil.
Milton Yutaka Nishiyama-JrLaboratory of Applied Toxinology, Butantan Institute, São Paulo, Brazil.
Denise V TambourgiImmunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: This study aimed to elucidate the transcriptomic landscape of tetracycline-associated protection in human keratinocytes in response to Results: Using transcriptomic profiling, we show that tetracycline upregulates Conclusion: Collectively, these transcriptomic findings, together with our previous functional studies, support a mechanistic framework in which tetracycline mitigates venom-induced pathology and highlight its potential as a therapeutic candidate for cutaneous loxoscelism and warrants targeted functional validation in future studies.

Indexed as

cutaneous loxoscelism treatmentLoxosceles venomsphingomyelinase Dtetracyclinewound healing

Identifiers

PMID42100328
PMCPMC13143931

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.