Efficacy and safety of an improved Xiao-Xu-Ming-Tang traditional Chinese medicine hot compress for preventing catheter-related bladder discomfort: a multicenter, randomized, double-blind, controlled trial.

Yujing Han, Zhihua Mi, Guanghui An, Bin Yang, Huixing Zhang, Dongmei Hong

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Yujing HanDepartment of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Zhihua MiShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Anesthesiology and Perioperative Medicine, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Guanghui AnDepartment of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Bin YangDepartment of Anesthesiology, The First Affiliated Hospital of Xiamen University, Fujian, China.

Huixing ZhangShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Anesthesiology and Perioperative Medicine, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Dongmei HongDepartment of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Catheter-related bladder discomfort (CRBD) occurs in 47-95% of patients recovering from general anesthesia, causing discomfort and increasing the risk of postoperative delirium. Xiao-Xu-Ming-Tang is a traditional Chinese medicine (TCM) concoction that has Methods: This was a multicenter, randomized, double-blind, controlled study. Ninety patients who underwent transurethral ureteral laser lithotripsy at three centers were included. Patients were randomly divided into two groups: the Chinese medicine (CM) group and the control group (salt packet (SP) group), at a ratio of 1:1. In the CM group, a hot compress (40-45 °C) of improved Xiao-Xu-Ming-Tang mixed with salt was placed above the pubic symphysis immediately after intubation. In the control group, one-tenth of the improved Xiao-Xu-Ming-Tang and salt mixture was used. Results: The Discussion: The aim of this trial was to evaluate the effect and safety of a hot compress of an improved Xiao-Xu-Ming-Tang powder and salt mixture for moderate and severe CRBD. These findings may provide a basis for the prevention of CRBD in clinical practice. Clinical trial registration: http://itmctr.ccebtcm.org.cn/, Identifier: ITMCTR2025000321.

Indexed as

catheter-related bladder discomforthot compressimproved Xiao-Xu-Ming-Tangprotocolrandomized controlled trial

Identifiers

PMID42100256

DOI10.3389/fmed.2026.1799106

PMCPMC13143896

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