ArticleFrontiers in endocrinology2026
Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice.Journal of neuroendocrinology · 2026Article
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7 authors.
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Abstract
Background: The neurotransmitter gamma-aminobutyric acid (GABA) plays a vital role in the modulation of reproductive function by controlling gonadotropin-releasing hormone (GnRH) secretion. Most kisspeptin neurons, which are key regulators of GnRH neurons, coexpress GABA and other neuropeptides. However, whether the expression of the vesicular GABA transporter (Vgat) in kisspeptin cells contributes to the reproductive phenotype of mice remains unclear. Methods: Brain slices from female vesicular GABA transporter-Cre/GFP (Vgat-Cre/GFP) mice were used to assess GABAergic coexpression in kisspeptin neurons during diestrus and proestrus. Mice carrying conditional ablation of Results: 50-60% of kisspeptin neurons in the anteroventral periventricular and rostral periventricular nuclei are GABAergic. However, the percentage of GABAergic kisspeptin neurons did not differ between proestrus and diestrus stages. Deletion of Discussion: These findings indicate that
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