Evidence map›Paper›PMID 42100160›Full record

ArticleFrontiers in chemistry2026

Development of a novel series of thiazole-based compounds with enhanced antiproliferative properties as tubulin polymerization inhibitors.

Lamya H Al-Wahaibi, Ali M Elshamsy, Taha F S Ali, Bahaa G M Youssif, Stefan Bräse, Mohamed Abdel-Aziz, Nawal A El-Koussi

Abstract read
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In one paragraph

Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lamya H Al-WahaibiDepartment of Chemistry, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Ali M ElshamsyPharmceutical Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Taha F S AliMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
Bahaa G M YoussifDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Stefan BräseInstitute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Mohamed Abdel-AzizMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
Nawal A El-KoussiDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In cancer therapy, inhibiting tubulin polymerization is a key approach for modifying microtubule dynamics required for cell survival and proliferation. Microtubule destabilizing agents (MDAs), also known as tubulin polymerization inhibitors, prevent tubulin heterodimers from forming microtubules, resulting in catastrophic cellular collapse. Methods: A novel series of thiazole-based compounds Results and Discussion: The results from the one-dose and five-dose studies demonstrate that

Indexed as

apoptosiscell cyclecolchicineNCItubulinWestern blot

Identifiers

PMID42100160
PMCPMC13143880

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.