ArticleMediterranean journal of rheumatology2026
Vision-Threatening Juvenile Lupus Retinopathy: A Report of Two Cases and Review of the Literature.
Article in Mediterranean journal of rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: The present case-based review aims to highlight two successfully treated cases of juvenile lupus retinopathy in a 15-year-old and a 17-year-old female with a review of literature highlighting the clinical profile and the treatment modalities used in those cases. Methods: A comprehensive literature search for vision-threatening juvenile lupus retinopathy on Medline/PubMed, Scopus, Web of Science, and Directory of Open Access Journals (DOAJ) revealed 27 cases from 25 case reports. Results: The interval between visual loss and treatment initiation was three days (range: 0- 2 months). The most prevalent fundoscopic findings were cotton-wool spots in 18 (66.7%). IV Cyclophosphamide (CYC) was the most commonly used immunosuppressive agent in 12 cases (44.4%). Retinal photocoagulation was the principal intraocular treatment modality employed in 11 cases (40.7%). The majority of JLR cases (17; 63%) showed excellent vision recovery. Conclusion: Juvenile lupus retinopathy is a rare yet severe manifestation of juvenile lupus and can have excellent outcomes if addressed early and aggressively.
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