Evidence map›Paper›PMID 42099998›Full record

ArticleMaterials today. Bio2026

Biomimetic double-layered electrospun nanofibrous scaffold with mussel adhesive protein coating and TGF-β3 encapsulation for enhanced tendon-bone healing in rotator cuff tears.

Sheng Fang, Yiming Wang, Huan Li, Hanwen Li, Zhuang Zhu, Huan Wang, Feng Han, Shenghao Wang, Dachuan Liu, Jiaying Li and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sheng FangDepartment of Articular Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China.
Yiming WangDepartment of Articular Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China.
Huan LiDepartment of Articular Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China.
Hanwen LiMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Zhuang ZhuMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Huan WangMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Feng HanDivision of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210000, China.
Shenghao WangMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Dachuan LiuMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Jiaying LiMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Chenxu ZhuDepartment of Articular Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China.
Qifan YuMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Li DongMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Chen CuiDepartment of Articular Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China.
Zhaofan ZhangDepartment of Articular Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China.
Jinbo LiuDepartment of Articular Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, 213003, China.
Bin LiMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Song ChenMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poor tendon-bone healing is a challenging issue and contributes to the high retear rate following rotator cuff tear (RCT) repair. The complex multiple tissue structure and limited chondrogenic capacity at the tendon-bone interface hinder effective regeneration and restoration of the enthesis. In this study, we developed a double-layered biomimetic nanofibrous scaffold encapsulating TGF-β3, further functionalized with a mussel adhesive protein (MAP) coating, to target the reconstruction of the torn rotator cuff's enthesis. The unique double-layer structure features distinct fibrous arrangements in each layer, mimicking the heterogeneous extracellular matrix structures of tendon and bone. This design provided a biomimetic environment conducive to the ingrowth of multiple tissues at the interface. In vitro studies demonstrated that the MAP-coated scaffold exhibited excellent biocompatibility and enhanced cell adhesion, facilitating tendon-bone interfacial integration. Moreover, the sustained release of TGF-β3 promoted stem cell recruitment and chondrogenic differentiation, as demonstrated both in vitro and in vivo. RNA-sequencing revealed that PI3K-Akt signaling pathway might be associated with the regulatory effects of the scaffold. In a rat RCT model, the composite scaffold significantly enhanced cartilage regeneration at the tendon-bone interface, restoring both enthesis structure and biomechanical properties. Therefore, the composite scaffold represents a promising strategy for improving tendon-bone healing and advancing interfacial tissue engineering in rotator cuff repair.

Indexed as

Electrospun scaffoldEnthesisMussel adhesive proteinRotator cuff tearTendon-bone interface

Identifiers

PMID42099998
PMCPMC13145380

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.