ArticleTransboundary and emerging diseases2026
A Self-Amplifying RNA Lipid Nanoparticle (saRNA-LNP) Vaccine Provides Effective Protection Against Porcine Epidemic Diarrhea.
Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Self-Amplifying RNA Lipid Nanoparticle (saRNA-LNP) Vaccine Provides Effective Protection Against Porcine Epidemic Diarrhea.Transboundary and emerging diseases · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of vaccine platforms capable of inducing sustained, potent, and cost-effective immunity remains a major challenge in veterinary vaccinology, particularly for coronaviruses, which are often associated with short-lived vaccine-induced protection. Here, we establish a self-amplifying RNA (saRNA) lipid nanoparticle (LNP) vaccine platform and evaluate its application using porcine epidemic diarrhea virus (PEDV) as a representative coronavirus model. A single vaccination elicited robust specific humoral and cellular immune responses. Vaccinated piglets exhibited significantly higher specific IgG and neutralizing antibody titers of PEDV-S (1:160) at 28 days postvaccination (dpv). Furthermore, elevated levels of serum IFN-γ and IL-4, along with enhanced CD4
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