Evidence map›Paper›PMID 42099974›Full record

ArticleFrontiers in neurology

Does acute-phase acupuncture at Hegu (LI04) promote facial nerve regeneration and upregulation of the PI3K/Akt/mTOR pathway? A hypothesis-generating study in a rabbit crush injury model.

Jin Song, Jianyun Zhang, Xinsheng He, Zhichun Zhu, Bingyan Liu, Yang Liu, Chen Liang, Binbin Jiang, Kesheng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jin SongRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.
Jianyun ZhangRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.
Xinsheng HeRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.
Zhichun ZhuRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.
Bingyan LiuRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.
Yang LiuRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.
Chen LiangRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.
Binbin JiangRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.
Kesheng ZhangRehabilitation and Treatment Center, Hunan Rehabilitation Hospital, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study used the rabbit facial nerve crush injury model to investigate the time-dependent effects of acupuncture at Hegu (LI04) on facial nerve regeneration and regulatory role of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway. Thirty-two New Zealand rabbits with facial nerve crush injury were randomly assigned to four groups (

Indexed as

acupuncturefacial nerve injuryHegu (LI04)intervention timingnerve regenerationPI3K/Akt/mTOR pathway

Identifiers

PMID42099974
PMCPMC13143614

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.