Evidence map›Paper›PMID 42099885›Full record

ReviewJB & JS open access

Biomarkers of Injury Severity in Shoulder Instability and Posttraumatic Osteoarthritis.

Patrick W Rooney, Reilly Corken, Mark D Wishman, Cory Call, Maria Bozoghlian, Carter Lane, Mitchell C Coleman, James V Nepola, Brendan M Patterson, Joseph W Galvin

Abstract readReview
In one paragraph

Review in JB & JS open access. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patrick W RooneyDepartment of Orthopedic Surgery, Madigan Army Medical Center, Joint Base Lewis-McChord, Washington.ORCID https://orcid.org/0000-0001-8812-171X
Reilly CorkenDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.ORCID https://orcid.org/0009-0004-6195-8973
Mark D WishmanDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Cory CallDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Maria BozoghlianDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.ORCID https://orcid.org/0000-0002-9729-0926
Carter LaneDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.ORCID https://orcid.org/0009-0000-8926-4229
Mitchell C ColemanDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.ORCID https://orcid.org/0000-0002-5116-801X
James V NepolaDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Brendan M PattersonDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Joseph W GalvinDepartment of Orthopedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.ORCID https://orcid.org/0000-0002-6139-9890

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

» There is a poor understanding of the significance of biomarkers in the blood, synovial fluid, and tissue in patients with shoulder instability and posttraumatic osteoarthritis (PTOA). » Identification of biomarkers associated with injury severity in shoulder instability may provide prognostic information to help guide surgical treatment algorithms. » Current evidence suggests that the biomarkers of periostin, tumor necrosis factor-alpha, IL1B, and cartilage oligomeric matrix protein are associated with injury severity in patients with recurrent anterior shoulder instability. » There is limited information on genetic, transcriptomic, and protein biomarkers which may indicate individuals who are at more risk for development of shoulder instability. » An improved understanding of the local biomolecular tissue response to first-time and recurrent anterior shoulder instability may contribute to the development of novel therapeutic strategies for gene and protein targets to halt the early cascade of PTOA.

Identifiers

PMID42099885
PMCPMC13148750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.