Evidence map›Paper›PMID 42099884›Full record

ArticleGlomerular diseases

Prediabetes in Children and Adults with Glomerular Disease.

William Rasmussen, Kayla Sifre, Nathaniel Putnam, Ashley E Rahimi, Eloise C Salmon, Elaine S Kamil, Sharon G Adler, Richard A Lafayette, Susan F Massengill, Yujie Wang and 1 more

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Article in Glomerular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

William RasmussenDivision of Pediatric Nephrology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Kayla SifreUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Nathaniel PutnamDivision of Pediatric Nephrology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Ashley E RahimiDivision of Pediatric Nephrology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Eloise C SalmonDivision of Pediatric Nephrology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Elaine S KamilDepartment of Pediatrics, Cedars-Sinai Medical Center and the David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Sharon G AdlerDivision of Nephrology and Hypertension at Harbor-UCLA Medical Center and The Lundquist Institute for Biomedical Innovation, Torrance, CA, USA.
Richard A LafayetteDivision of Nephrology, Department of Medicine, Stanford University, Stanford, CA, USA.
Susan F MassengillDepartment of Pediatrics/Pediatric Nephrology, Levine Children's Hospital at Atrium Health, Charlotte, NC, USA.
Yujie WangMedical Data Science Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Zubin J ModiDivision of Pediatric Nephrology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Glomerular disease (GD) and diabetic nephropathy are both leading causes of end-stage kidney disease (ESKD) in the USA. Much is known about each individually, but less of any interactions between the two. There is emerging evidence that factors specific to GD, such as immunosuppression, may increase the risk of diabetes, which in turn could compound glomerular filtration rate decline through the mechanisms of diabetic nephropathy. Understanding the epidemiology of prediabetes and diabetes in GD patients may inform improved screening and prevention practices in this population and may lead to strategies that mitigate progression to ESKD. The aim of this study was to delineate risk factors for prediabetes in GD. Methods: Data were extracted from University of Michigan and Kidney Research Network electronic health record registry with patients classified by age at GD at diagnosis or first nephrology appointment (child [age <18 y, Results: A total of 148 patients (19.9% of cohort) developed prediabetes in study follow-up. Adult GD patients were more likely than pediatric GD patients to progress (HR: 1.73 [95% CI: 1.19-2.50]), as were patients with uncontrolled hypertension (HR: 9.61 [95% CI: 3.02-30.61]) and controlled hypertension (HR: 6.50 [95% CI: 1.91-22.18]). The use of beta-blockers, statins, or diuretics was also associated with higher prediabetes risk (HR: 2.87 [95% CI: 1.98-4.17]). Conclusion: Adult age, worsening control of hypertension, and certain medications were associated with increased prediabetes risk in preexisting GD. More data, in particular prospective data, are needed to refine risk relationships and incidence data.

Indexed as

Glomerular diseasePrediabetesRisk

Identifiers

PMID42099884
PMCPMC13148812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.