ArticleCurrent opinion in biomedical engineering2025
Hyaluronic acid-based models of the brain microenvironment: Challenges and advances.
Article in Current opinion in biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Understanding Glioblastoma Dynamics Using 3D Organoids and Engineered Extracellular Matrix.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanobiology of hippocampal neurogenesis: directing neural stem cell fate through physical cues.Frontiers in molecular neuroscience · 2026Review
- Understanding proneural-mesenchymal transition using patient-derived glioma stem-like cell (GSC) organoids and engineered extracellular matrix.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
While hyaluronic acid (HA) extracellular matrix (ECM) models continue to provide valuable insights into brain physiology and disease, much room for improvement remains in terms of capturing the cellular and structural complexity of the brain microenvironment. Here we review next-generation HA models that are aimed at better capturing brain microenvironmental complexity. We discuss functionalization and crosslinking strategies designed to improve HA stability and biocompatibility. We also cover efforts to incorporate ECM proteins and stromal elements into HA hydrogels, including astrocytes, endothelial cells, and macrophages. We conclude with a brief discussion of nascent advancements and applications of these models, ranging from the reconstruction of multicellular stromal structures to the development of high-throughput screening platforms. This new suite of matrix technologies and the resulting applications should contribute greatly to mechanistic and therapeutic discovery in brain physiology and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.