Evidence map›Paper›PMID 42099701›Full record

ArticleBrain & spine2026

Trans orbital eyebrow approach for selective resections in mesial temporal lobe epilepsy: Technical aspects and preliminary case series.

Sébastien Froelich, Emmanuel Mandonnet, Yohan Caudron, Tingting Jiang, Arianna Fava, Thibault Passeri, Agathe Laurent, Adrien Zanin, Bertrand Devaux, Francine Chassoux

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Article in Brain & spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Sébastien FroelichDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Emmanuel MandonnetDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Yohan CaudronDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Tingting JiangDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Arianna FavaDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Thibault PasseriDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Agathe LaurentDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Adrien ZaninDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Bertrand DevauxDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.
Francine ChassouxDepartment of Neurosurgery, Lariboisiere Hospital, Paris, France andParis-City University, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Selective amygdalo-hippocampectomy (SAH) is commonly performed in drug-resistant mesial temporal lobe epilepsy (MTLE) with seizure-free outcome in 70-80% of patients, however cognitive risks with respect to surgical approaches remain debated. Research question: The preliminary experience of a new surgical route through the orbit are evaluated with the aim to improve the benefits/risks of SAH. Methods: Patients were recruited among a cohort of 100 patients investigated in the Epilepsy Unit of the department of Neurosurgery, between 2022 and 2024. A SAH through a transorbital approach with an eyebrow incision was performed in 3 patients (2 males, 22-51 years) after investigation for pure MTLE (right side in 2, non-lesional in 1).Surgical outcome was assessed with respect to seizures according to the International League Against Epilepsy (ILAE) classification. Results: No local or general complications occurred postoperatively except a transient diplopia due to ocular oedema. Mean volume of resection was of 9.2 cc, and virtual dissection of tractograms demonstrated that the resection cavity spared the optic, uncinate and inferior longitudinal pathways in all cases.With a 12 to 31 month-follow-up (mean 22 months), seizure-free outcome (ILAE class 1) was obtained in all patients. Neuropsychological evaluation showed increased or stable cognitive and memory performances, with an improvement of quality of life (QOL) in all. Aesthetical results were excellent. Conclusion: Transorbital eyebrow approach is safe and effective for SAH, with a positive impact on cognitive functions and QOL. Although preliminary, these findings suggest that it may be an option in patients with pure MTLE.

Indexed as

Eyebrow incisionMesial temporal lobe epilepsySelective amygdalohippocampectomySurgical outcomeTransorbital approach

Identifiers

PMID42099701
PMCPMC13147762

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