Evidence map›Paper›PMID 42099658›Full record

ArticleCurrent fungal infection reports2026

Updates on Chromoblastomycosis: Evolving Insights in Clinical Management and Therapeutic Strategies.

Katarina Popovic, Andrés F Henao-Martínez, Marcus de Melo Teixeira, Elton Bill Amaral de Souza, Mendrika Rakotoarisaona, Nelson Iván Agudelo Higuita

Abstract read
In one paragraph

Article in Current fungal infection reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katarina PopovicDepartment of Internal Medicine, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
Andrés F Henao-MartínezDepartment of Medicine, Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Marcus de Melo TeixeiraNúcleo de Medicina Tropical, University of Brasília, Brasilia, Brazil.
Elton Bill Amaral de SouzaCentro de Pesquisas em Medicina Tropical de Rondônia, Porto Velho, Brazil.
Mendrika RakotoarisaonaThe Centre Hospitalier Universitaire de Soins et de Santé Publique d'Analakely, Antananarivo, Madagascar.
Nelson Iván Agudelo HiguitaDivision of Infectious Diseases, Department of Medicine, University of Oklahoma Health Campus, Oklahoma City, OK, USA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
NCRR NIH HHS UL1 RR025780
6 · The paper itself

Abstract

Purpose of Review: The aim of this review is to provide an in-depth overview of chromoblastomycosis, with emphasis on emerging management strategies and therapeutic options, and to underscore potential gaps in the literature and priorities for future research. Recent Findings: Among the newer triazoles, posaconazole has demonstrated greatest therapeutic potential in the treatment of chromoblastomycosis, including for severe and refractory disease. Adjunctive immunomodulatory therapies such as glucan, imiquimod, and acitretin have shown potential as well. Several novel and repurposed agents also have potential activity against dematiaceous fungi, including tricyclazole, HIV peptidase inhibitors, 1,10-phenanthroline-5,6-dione, and benzimidazoles. A recently proposed combination protocol with debulking, intralesional amphotericin B, and oral terbinafine (DAT protocol) achieved cure in all 16 included patients in a 2025 case series. While excisional surgery remains the preferred physical therapeutic modality, several reports have shown favorable results with both photodynamic and heat therapy. Summary: Chromoblastomycosis continues to pose a therapeutic challenge, requiring prolonged antifungal therapy often combined with physical therapeutic modalities. Improved access to diagnostics and early intervention remain essential to reducing global disease burden.

Indexed as

ChromoblastomycosisChromomycosisDematiaceous FungiMedlar BodyMelanized FungiNeglected Tropical Diseases

Identifiers

PMID42099658
PMCPMC13148373

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.