Evidence map›Paper›PMID 42099629›Full record

Observational studyFrontiers in immunology2026

Particularly strong immune response to influenza vaccination in patients with decompensated liver cirrhosis linked to systemic inflammation.

Janyn Heisig, Valerie Ohlendorf, Nhan Nguyen, Peggy Riese, Stephanie Trittel, Liang Zhou, Ahmed Alaswad, Heiner Wedemeyer, Anke Kraft, Yang Li and 3 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Janyn HeisigDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Valerie OhlendorfDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.
Nhan NguyenCentre for Individualised Infection Medicine (CiiM), A Joint Venture of Helmholtz Centre for Infection Research and Hannover Medical School, Hannover, Germany.
Peggy RieseDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Stephanie TrittelDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Liang ZhouCentre for Individualised Infection Medicine (CiiM), A Joint Venture of Helmholtz Centre for Infection Research and Hannover Medical School, Hannover, Germany.
Ahmed AlaswadCentre for Individualised Infection Medicine (CiiM), A Joint Venture of Helmholtz Centre for Infection Research and Hannover Medical School, Hannover, Germany.
Heiner WedemeyerDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.
Anke KraftDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.
Yang LiCentre for Individualised Infection Medicine (CiiM), A Joint Venture of Helmholtz Centre for Infection Research and Hannover Medical School, Hannover, Germany.
Markus CornbergDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.
Carlos A GuzmánDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Benjamin MaasoumyDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH), Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: Seasonal influenza virus infections represent a global health threat, especially in high-risk groups, including patients with liver cirrhosis that are considered to be immunocompromised, in particular in decompensated stages. Although vaccination is the most cost-efficient tool to prevent infectious diseases, information about vaccine performance in these patients is scarce. This study aimed to dissect the immunological responses to seasonal influenza vaccines in patients suffering from compensated or decompensated liver cirrhosis. Approach and results: Prospective, observational studies during the influenza seasons 2019-2020 (1 Conclusion: Patients with liver cirrhosis can mount an efficient response to seasonal influenza vaccines that is even superior in more advanced stages of cirrhosis. Systemic inflammation caused by liver cirrhosis may contribute to distinct humoral and cellular vaccine responses.

Indexed as

InflammationInfluenza, HumanInfluenza VaccinesLiver CirrhosisAdultAgedAntibodies, NeutralizingAntibodies, ViralCytokinesFemaleHumansImmunity, CellularMaleMiddle AgedProspective StudiesVaccinationAntibodies, NeutralizingAntibodies, ViralCytokinesInfluenza Vaccinescompensated and decompensated cirrhosishumoral- and cellular immunityinfluenza vaccineliver cirrhosisliver disease

Identifiers

PMID42099629
PMCPMC13143674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.