Evidence map›Paper›PMID 42099623›Full record

ArticleFrontiers in immunology2026

Plasma soluble cellular prion protein reflects ischemic stroke severity and is associated with circulating CD4

Shuqin Hou, Yue Lang, Xiang Yin, Weiguanliu Zhang, Xiaona Li, Li Cui

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuqin HouDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Yue LangDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Xiang YinDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Weiguanliu ZhangDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Xiaona LiDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Li CuiDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The soluble form of cellular prion protein (PrP Methods: In this single-center prospective cohort study, we consecutively enrolled patients with acute ischemic stroke admitted to the Department of Neurology, The First Hospital of Jilin University (Changchun, China) between June 2023 and October 2024 within 48 h of symptom onset (for wake-up stroke, onset was defined as the last known well). Fasting venous blood was collected the morning after admission. Stroke severity was categorized by admission NIHSS as mild (≤6) or moderate-to-severe (>6), and volunteers from the Health Examination Center served as controls. Circulating CD4 Results: Plasma soluble PrP Conclusions: Plasma soluble PrP

Indexed as

CD4-Positive T-LymphocytesIschemic StrokePrion ProteinsAgedBiomarkersFemaleHumansMaleMiddle AgedProspective StudiesSeverity of Illness IndexBiomarkersPrion ProteinsbiomarkerCD4+ T cellscellular prion proteinischemic strokeT-helper subsets

Identifiers

PMID42099623
PMCPMC13143613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.