SynthesisFrontiers in immunology2026
Current progress and emerging trends of car-based immunotherapy for hepatocellular carcinoma: a data-driven atlas from multidatabase integration.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hepatocellular carcinoma (HCC) is a highly prevalent and lethal malignancy worldwide, with its incidence steadily rising over recent decades. Conventional treatments, including chemotherapy, surgery, immunotherapy, Targeted Therapy and radiotherapy, offer limited therapeutic benefit. Chimeric antigen receptor (CAR)-based immunotherapy has emerged as a promising strategy for HCC, yet significant challenges remain. This study aims to provide a comprehensive overview of the current landscape and future prospects of CAR-based immunotherapy in HCC. Methods: On September 30, 2025, we conducted a systematic literature search in the Web of Science Core Collection (WoSCC) and Scopus databases, targeting publications from 2016 to 2025. Full records and cited references were extracted and screened. Data-driven analyses and visualizations were performed using CiteSpace, Microsoft Excel 2019, VOSviewer, and R software. Results: A total of 5,210 publications were included in the analysis. The number of studies in this field has increased sharply since 2019 and is projected to continue rising. China, particularly its universities, leads global research in this area. Most influential studies were concentrated around 2019. Research hotspots have shifted from traditional pharmacology toward gene regulation and the tumor microenvironment (TME). Collaboration networks among authors, countries, and institutions indicate a growing trend toward multidisciplinary cooperation. Conclusion: CAR-based immunotherapy for HCC remains in its early stages of development. Future research should prioritize enhancing therapeutic efficacy and safety, fostering international collaboration, and promoting interdisciplinary approaches to improve clinical outcomes for HCC patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.