ArticleChemical science2026
An extrinsic enzyme-activatable fluorescent probe for high-contrast tumor imaging.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- High-sensitivity SERS nanosensor for precise in situ tracking of caspase-1 during pyroptosis in macrophages.Mikrochimica acta · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant tumors pose a major threat to human health, and the effectiveness of treatment largely depends on accurate early diagnosis and complete resection. Although fluorescence imaging offers high sensitivity and enables real-time visualization for intraoperative navigation, conventional fluorescent dyes are limited by photobleaching, poor targeting, and low signal-to-noise (S/N) ratios. These limitations result in false-negative or false-positive outcomes, thereby compromising the precision of surgery and the validity of subsequent treatment decisions. Herein, we developed a fluorescent probe, TMN-CPG, which is specifically activated by carboxypeptidase G2 (CPG2), an enzyme notable for prodrug activation in antibody-directed enzyme prodrug therapy (ADEPT). Upon CPG2-mediated hydrolysis of the TMN-CPG amide bond, the highly fluorescent TMN-NH
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.