Evidence map›Paper›PMID 42099542›Full record

ArticleChemical science2026

Stereoselective hydrogen isotope exchange on nicotinamide cofactors through flavoenzyme microscopic reversibility.

Christopher W Otun, Michael Yuen, Harry J Spacey, Carlo Bawn, Matthew J Cliff, Francesco Falcioni, Ryan A Bragg, Charles S Elmore, Sam Hay, Jack S Rowbotham

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christopher W OtunManchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.ORCID https://orcid.org/0009-0007-2445-126X
Michael YuenManchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.ORCID https://orcid.org/0009-0007-5236-6054
Harry J SpaceyManchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.
Carlo BawnManchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.ORCID https://orcid.org/0000-0002-2935-2312
Matthew J CliffManchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.
Francesco FalcioniEarly Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Cambridge UK.
Ryan A BraggEarly Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Cambridge UK.ORCID https://orcid.org/0000-0002-7545-8628
Charles S ElmoreEarly Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Gothenburg Sweden.ORCID https://orcid.org/0000-0001-7434-8307
Sam HayManchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.ORCID https://orcid.org/0000-0003-3274-0938
Jack S RowbothamManchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.ORCID https://orcid.org/0000-0002-1590-8674

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a panel of flavoenzymes with the ability to catalyse stereoselective hydrogen isotope exchange (HIE) between

Identifiers

PMID42099542
PMCPMC13147284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.