Evidence map›Paper›PMID 42099540›Full record

ArticleChemical science2026

Highly Cα-regio-, enantio- and diastereoselective Mukaiyama-type annulation of siloxyfurans: stereodivergent synthesis of multi-stereogenic tricyclic γ-lactones.

Lifei Gan, Zi-Qing Li, Tao Chen, Xuanchen Wan, Junyang Zhang, Jiangtao Ren, Ming Jiang, Penglong Cao, Jinhai Huang, Yu-Hua Deng and 5 more

Abstract read
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Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lifei GanKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Zi-Qing LiCollege of Chemistry, Central China Normal University Wuhan 430079 China zhihanzhang@ccnu.edu.cn.
Tao ChenKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Xuanchen WanKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Junyang ZhangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Jiangtao RenKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Ming JiangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Penglong CaoKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Jinhai HuangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Yu-Hua DengKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.ORCID https://orcid.org/0000-0002-1983-8490
Fangzhi PengKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Run TianYunnan University Affiliated Hospital, Yunnan University Kunming 650000 China.
Yingcheng WangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.
Zhihan ZhangCollege of Chemistry, Central China Normal University Wuhan 430079 China zhihanzhang@ccnu.edu.cn.
Zhihui ShaoKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University Kunming 650091 China dengyuhua@ynu.edu.cn ycwang@ynu.edu.cn zhihui_shao@hotmail.com.ORCID https://orcid.org/0000-0003-4531-3417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first Cα-selective asymmetric reaction of 2-siloxyfurans, a class of versatile nucleophiles, has been developed with both high enantioselectivity and diastereoselectivity. Moreover, by changing the achiral co-catalyst to a newly developed combined co-catalyst, a rare diastereoselective reversal was achieved, selectively yielding the thermodynamically less stable diastereomer. DFT and experimental studies reveal that the observed Cα-selectivity results from dispersion and electrostatic interactions between 2-siloxyfurans and the electrophile/catalyst, while the diastereodivergent synthesis arises from a divergent C-O bond formation

Identifiers

PMID42099540
PMCPMC13147288

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