Evidence map›Paper›PMID 42099513›Full record

ArticleFrontiers in pediatrics2026

Morphological and functional echocardiographic findings in pediatric patients diagnosed with hypermobile Ehlers-Danlos syndrome.

Walter Vignaroli, Gioia Mastromoro, Carolina Putotto, Filippo Camerota, Claudia Celletti, Mauro Celli, Luca Celli, Anna Zambrano, Francesco Carlomagno, Emanuele Monda and 3 more

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors.

Walter VignaroliDepartment of Cardiac Surgery, San Carlo di Nancy Hospital, GVM Care & Research, Rome, Italy.
Gioia MastromoroDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Carolina PutottoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Filippo CamerotaPhysical Medicine and Rehabilitation, Sapienza University of Rome, Rome, Italy.
Claudia CellettiDepartment of Life Sciences, Health, and Health Profession, Link Campus University, Rome, Italy.
Mauro CelliDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Luca CelliDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Anna ZambranoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Francesco CarlomagnoDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Emanuele MondaInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Annapaola CirilloInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Bruno MarinoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Paolo VersacciDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypermobile Ehlers-Danlos syndrome (hEDS) is a connective tissue disorder that may involve the cardiovascular system. While mitral valve prolapse (MVP) and aortic root dilatation (ARD) have been documented in adults with hEDS, their prevalence in children remains unclear. Methods: This study evaluated 28 pediatric patients with hEDS and 28 age- and body surface area-matched healthy controls using two-dimensional echocardiography, Doppler, Tissue Doppler Imaging (TDI), and Speckle Tracking Echocardiography (STE), including global longitudinal strain (GLS) analysis. Results: Nine hEDS patients (32%) exhibited MVP. Although aortic root and ascending aorta Z-scores remained within the normal range, they were significantly higher in hEDS patients compared to controls. TDI revealed reduced late diastolic septal myocardial velocities ( Discussion: These findings suggest that cardiac alterations such as MVP can manifest in childhood and that subtle myocardial impairment can occur despite normal EF. STE and GLS analyses are valuable tools for the early detection of functional abnormalities. Routine cardiac follow-up in pediatric hEDS patients may help identify and monitor these early cardiovascular changes, potentially improving long-term outcomes.

Indexed as

aortic dilatationcardiovascular anomaliesechocardiographyEhlers-Danlos syndromeglobal longitudinal strain

Identifiers

PMID42099513
PMCPMC13144140

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