Evidence map›Paper›PMID 42099462›Full record

ArticleiMeta2026

Spinal cord injury induces acute microbiome shock and system-wide transcriptomic reprogramming.

Chi Zhang, Yufei Du, Mingxin Wu, Chuang Li, Ruizhi Jiang, Enlin Qi, Shaolong Li, Xianfu Yi, Bo Chu, Shiqing Feng and 1 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chi ZhangDepartment of Orthopaedics The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University Jinan China.ORCID https://orcid.org/0000-0003-1288-9006
Yufei DuDepartment of Endocrinology and Metabolism The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University Jinan China.
Mingxin WuDepartment of Spine Osteopathia The First Affiliated Hospital of Guangxi Medical University Nanning China.
Chuang LiDepartment of Orthopaedics The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University Jinan China.
Ruizhi JiangDepartment of Orthopaedics Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University Jinan China.
Enlin QiDepartment of Orthopaedics Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University Jinan China.
Shaolong LiDepartment of Orthopaedics Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University Jinan China.
Xianfu YiDepartment of Bioinformatics, School of Basic Medical Sciences Tianjin Medical University Tianjin China.
Bo ChuDepartment of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine Shandong University Jinan China.
Shiqing FengDepartment of Orthopaedics The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University Jinan China.
Hengxing ZhouDepartment of Orthopaedics Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University Jinan China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the systemic consequences of spinal cord injury (SCI), with a particular focus on alterations in the gut microbiome and multi-organ transcriptomic responses. We identify a rapid and severe disruption of the gut microbiota-termed "microbiome shock"-that emerges within 12 h post-SCI and persists before gradually resolving by 5 days post-injury. To support further research in this field, we established an open-access resource, the Spinal Cord Injury Gut Microbiome and Multi-Organ Gene Expression Atlas (SCIGAMA).

Identifiers

PMID42099462
PMCPMC13147949

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.