Evidence map›Paper›PMID 42099453›Full record

ArticleiMeta2026

Single-cell transcriptomics reveals cellular heterogeneity and phenotypic transitions of smooth muscle cells in aortic dissection.

Liang Shao, Fan Hu, Ling-Na Zhao, Jian-Ping Luo, Peng-Tao Zou, Xiu Liu, Shao-Yi Zheng, Cong Chen, Lin-Xiong Ye, Yu-Xuan Zhou and 3 more

Abstract readLetter
In one paragraph

Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liang ShaoDepartment of Cardiology, the Second Affiliated Hospital University of South China Hengyang China.ORCID https://orcid.org/0000-0003-2676-3332
Fan HuDepartment of Neurology, Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College Nanchang China.
Ling-Na ZhaoDepartment of Cardiovascular Surgery, Nanfang Hospital Southern Medical University Guangzhou China.
Jian-Ping LuoDepartment of Cardiology Ganzhou People's Hospital Ganzhou China.
Peng-Tao ZouDepartment of Cardiology, Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College Nanchang China.
Xiu LiuDepartment of Cardiovascular Surgery, Nanfang Hospital Southern Medical University Guangzhou China.
Shao-Yi ZhengDepartment of Cardiovascular Surgery, Nanfang Hospital Southern Medical University Guangzhou China.
Cong ChenDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Lin-Xiong YeDepartment of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy Fudan University Shanghai China.
Yu-Xuan ZhouDepartment of Cardiology, Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College Nanchang China.
Jiaqi ZhangDepartment of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy Fudan University Shanghai China.
Kaidi JinDepartment of Forensic Medicine, School of Basic Medical Sciences Fudan University Shanghai China.
Ping ZhangDepartment of Neurology, Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College Nanchang China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We utilized single-cell RNA sequencing (scRNA-seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis identified five smooth muscle cell (SMC) subtypes, with SMC2 linked to fibrosis and SMC3 associated with inflammation. Thrombus-positive AD samples showed upregulated angiopoietin-like 4 (

Identifiers

PMID42099453
PMCPMC13147948

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.