ArticleiMeta2026
Spatial multi-omics identifies a NOTCH3-mediated capillary-mCAF crosstalk driving immune exclusion in hepatocellular carcinoma.
Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Review
- Article
- PTM-Related Signatures Predict Lymph Node Metastasis and Shape Microenvironment in Hepatocellular Carcinoma: A Single-Cell and Bulk Integrated Analysis.Journal of hepatocellular carcinoma · 2026Article
- Associations of Type 2 Diabetes with Tumor Budding and Microvascular Invasion in Resected Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2026Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrosis induced immune exclusion is a hepatocellular carcinoma (HCC) hallmark, underscoring the key role of cancer-associated fibroblasts (CAFs) in immune regulation. Through HCC spatial multi-omics data and integrating pan-cancer scRNA-seq profiles of CAFs under immune checkpoint blockade (ICB) treatment, we characterized a potential crosstalk between capillaries and CAFs mediated by the NOTCH signaling pathway. Specifically, endothelial DLL4-NOTCH3 signaling appears to be associated with matrix-producing CAFs (mCAFs) polarization, leading to extracellular matrix remodeling and the establishment of immune-restrictive niches that hinder T cell infiltration. Perturbation of NOTCH signaling attenuated mCAF differentiation and enhanced T cell infiltration in vitro, and was associated with improved ICB response in both spontaneous and orthotopic HCC mouse models. Collectively, our findings suggest that capillary-mCAFs communication through the NOTCH pathway, particularly
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.