ArticleFrontiers in behavioral neuroscience2026
A panel of medaka isogenic lines suggests individual, seasonal, and sexual genetic variation of
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Once recognized only in humans, variance in the cognitive phenotype is now acknowledged in a range of vertebrate species. However, our understanding of its underlying causes is still incomplete. Brain-derived neurotrophic factor (BDNF) is an essential protein for brain functioning and plays a key role in cognitive processes such as learning and memory, including interindividual variation. Environmental factors influence BDNF abundance in the brain, and so do genetic polymorphisms in humans and mice. Methods: Using the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel of near-isogenic medaka lines, which captures a wide range of natural genetic variation in this species, we investigated the potential quantitative genetic variation in Results: Our findings show significant variation in Discussion: These results suggest that quantitative genetic differences, in concert with environmental influences, contribute to
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