ReviewFrontiers in cell and developmental biology2026
NELL-1: role and mechanisms in disease pathogenesis and development.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
NELL-1 (NEL-like protein 1) is a multifunctional secreted glycoprotein that has been implicated in a variety of biological processes, including skeletal development, immune regulation, and tumorigenesis. Despite its significance, the regulatory mechanisms of NELL-1 across different tissues, the diversity of its signaling pathways, and its context-dependent roles in disease are not fully elucidated. This gap in understanding hinders the systematic development and clinical translation of potential applications. Current research suggests that NELL-1 influences skeletal development and regeneration through pathways such as Wnt/β-catenin, MAPK, and Runx3-Indian hedgehog (Ihh). Additionally, it plays crucial roles in conditions such as membranous nephropathy, various tumors, and neurodevelopmental disorders. The distinct isoforms of NELL-1, such as NELL-1
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