ReviewJSES reviews, reports, and techniques2026
Histologic outcomes of rotator cuff patch augmentation: a literature review.
Review in JSES reviews, reports, and techniques, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rotator cuff repairs frequently fail due to inadequate biologic healing at the tendon-bone interface. Patch augmentation has emerged as a strategy to enhance this process by promoting cellular infiltration, organized collagen deposition, and matrix remodeling. This review evaluates the histologic and biochemical effects of scaffold augmentation, compares different augmentation materials, and analyzes commercially available implants based on animal and human studies. A Preferred Reporting Items for Systematic reviews and Meta-Analyses-guided search of PubMed, Scopus, and Embase through May 2025 identified 42 eligible studies that reported histologic or biochemical outcomes following augmented rotator cuff repair. Dermal matrix patches demonstrated accelerated early neovascularization and collagen synthesis but were associated with incomplete fibrocartilage formation and persistent type III collagen. Extracellular matrix-derived patches showed improved collagen alignment but were linked to inflammatory responses. Synthetic polymers produced dense type I collagen with variable immune reactions, while biologically augmented scaffolds achieved high collagen density with minimal macrophage infiltration. Demineralized bone matrix demonstrated early fibrocartilage integration, mature collagen crimp, and low inflammatory response by 8 weeks. Among commercially available products, REGENETEN, ArthroFLEX, and Dynagraft II showed the most complete scaffold resorption and tendon-like remodeling, whereas Conexa and Zimmer patches demonstrated consistent integration, and Permacol and BioEnthesis showed limited improvements. Overall, patch augmentation appears to enhance biologic healing after rotator cuff repair; however, definitive conclusions are limited by the lack of high-quality human studies. These findings may inform scaffold selection and future implant design aimed at improving tendon-bone healing and reducing retear rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.