ReviewCureus2026
Biologically Driven Tooth Regeneration: A Scoping Review of Stem Cell-Based Approaches.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regenerative dentistry is an emerging branch of medicine that focuses on restoring biological tooth structures using stem cells, biomimetic scaffolds, and signaling factors, rather than relying on traditional man-made materials. Current treatments, such as fillings and crowns, can rebuild lost tooth structures but cannot replicate the structure and function of dentin-pulp tissues. Recent preclinical and early human studies have explored various stem-cell sources, including dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), and periodontal ligament stem cells (PDLSCs). Among these, DPSCs and SHED have been the most extensively investigated. Most studies have shown that, when combined with pro-angiogenic factors such as vascular endothelial growth factors (VEGFs) and fibroblast growth factors (FGFs), collagen and hydrogel scaffolds are effective in regenerative dentistry. These studies have demonstrated successful tissue formation, mineralization, and vascularization in animal models and early human trials. However, considerable variability exists among studies due to differences in experimental design, stem-cell sources, scaffold materials, and growth-factor use, leading to inconsistent outcomes. Despite these advances, the literature remains fragmented and largely preclinical. Only a limited number of human studies are available, and variability among studies remains substantial. Existing reviews often focus on a single component, such as a specific stem-cell type or scaffold property, rather than integrated regenerative systems. This scoping review, conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines, synthesizes available preclinical and early clinical evidence and identifies combinations of stem cells, scaffolds, and signaling molecules with the greatest potential for predictable dental tissue regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.