Evidence map›Paper›PMID 42099290›Full record

SynthesisJournal of endovascular therapy : an official journal of the International Society of Endovascular Specialists2026

Long-term Cardiovascular and All-Cause Mortality following Elective Infrarenal Repair of the Abdominal Aortic Aneurysm: A Systematic Review and Meta-analysis.

Samira E M van Knippenberg, Cecilia Fenelli, Susan van Dieren, Ronak Delewi, Ron Balm, Kak Khee Yeung

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samira E M van KnippenbergDepartment of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0009-0007-1736-8169
Cecilia FenelliDepartment of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Susan van DierenDepartment of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Ronak DelewiMicrocirculation, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Ron BalmDepartment of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Kak Khee YeungAtherosclerosis & Ischemic Syndromes, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.ORCID 0000-0002-8455-286X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with abdominal aortic aneurysms (AAAs) have poor survival rates after aneurysm repair compared with the general population, potentially due to increased cardiovascular risk. This systematic review and meta-analysis aimed to assess the long-term incidence of all-cause and cardiovascular mortality after elective, infrarenal AAA repair.

methodThe Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed (PROSPERO ID: CRD42022344547). Studies published in PubMed, Web of Science, and COCHRANE databases between January 2013 and May 2023 with a mean follow-up time of ≥5 years were included. A weighted linear regression analysis was performed to determine the annual incidence of all-cause and cardiovascular mortality five years after AAA repair. A random effects model calculated the overall incidence rates per 1000 person-years (PY). Endovascular aneurysm repair (EVAR) and open surgical repair (OSR) were compared.

resultsNineteen studies with 84 212 patients (mean follow-up: 68.9 [±13.3] months) were included. Common preoperative cardiovascular comorbidities included hypertension (74.4%), dyslipidemia (43.6%), and coronary artery disease (27.6%). At five years, the mean all-cause mortality was 29.78%, and cardiovascular mortality was 11.98%, with an annual increase of 6.59% and 2.46%, respectively (R

conclusionThe long-term all-cause and cardiovascular mortality remain high following elective, infrarenal AAA repair. These findings highlight a much needed optimization and emphasis of cardiovascular risk management, to minimize the long-term incidence of cardiovascular mortality in patients with AAA following surgical intervention.Clinical ImpactThis study evaluated the long-term outcomes of cardiovascular and all-cause mortality rates following elective repair of the infrarenal abdominal aortic aneurysm. The results of this systematic review and meta-analysis emphasizes the suboptimal cardiovascular risk profile observed in this patient population. Futhermore, it highlights the importance of optimization and emphasis of cardiovascular risk management, including in the long-term after surgical intervention.

Indexed as

Aortic Aneurysm, AbdominalBlood Vessel Prosthesis ImplantationCardiovascular DiseasesEndovascular Aneurysm RepairEndovascular ProceduresAgedAged, 80 and overCause of DeathComorbidityElective Surgical ProceduresFemaleHeart Disease Risk FactorsHumansIncidenceMaleMiddle Agedabdominal aortic aneurysmcardiovascular diseasecardiovascular mortalitymortality

Identifiers

PMID42099290
PMCPMC13172124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.