ArticleJournal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
Serum Endothelial Glycocalyx Biomarkers in Dogs Anesthetized With Isoflurane or Sevoflurane: A Randomized, Prospective Study.
Article in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Serum Endothelial Glycocalyx Biomarkers in Dogs Anesthetized With Isoflurane or Sevoflurane: A Randomized, Prospective Study.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo compare serum syndecan-1 (SDC1) and hyaluronan (HA) concentrations in dogs receiving sevoflurane or isoflurane during general anesthesia and to assess factors associated with changes in these biomarkers during anesthesia.
designProspective, randomized controlled trial.
settingUniversity teaching hospital. ANIMALS: Twenty-eight client-owned dogs scheduled for magnetic resonance imaging and potential surgery for intervertebral disc disease were enrolled.
interventionsDogs were randomly assigned to either the isoflurane or sevoflurane group, with 14 dogs in each group. Serum SDC1 and HA concentrations were measured before and after anesthesia using commercial ELISA kits validated for dogs. Primary outcomes were SDC1 and HA concentrations before and after anesthesia, as well as their changes during anesthesia, defined as postanesthetic minus preanesthetic biomarker concentration (ΔSDC1 and ΔHA). Secondary outcomes included duration of anesthesia, intraoperative medications, perioperative complications, and total intravenous crystalloid volume administered. MEASUREMENTS AND MAIN
resultsNo significant differences in postanesthetic SDC1 were observed between the sevoflurane (14.3 ng/mL, 6.5-40.6) and isoflurane groups (20.0 ng/mL, 13.6-24.2; p = 0.129). Similarly, postanesthetic HA concentrations did not differ significantly between the sevoflurane (14.2 ng/mL, 7.3-36.8) and isoflurane groups (14.2 ng/mL, 0.32-44.1; p = 0.560). However, HA levels significantly decreased after anesthesia in both groups (p = 0.013 and p = 0.011).
conclusionsNo differences in endothelial glycocalyx effects were observed between groups that received sevoflurane or isoflurane anesthesia.
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